BAEG, Gyeong Hun

副教授

教育背景

博士后研究员(美国波士顿哈佛医学院霍华德休斯医学院遗传学系)

博士(日本大阪大学医学研究院生物医学科学)

研究领域
利用果蝇作为体内模型生物的干细胞和癌生物学、纳米毒理学
电子邮件
ghbaeg@cuhk.edu.cn
个人简介

BAEG Gyeong Hun 教授,在日本大阪大学医学研究院获得了生物医学博士学位,在那里他进行了癌症研究。为了扩展对癌症生物学的知识,加入了哈佛医学院的Norbert Perrimon教授的实验室,Howard Hughes医学院的博士后研究员,并利用果蝇作为体内模型系统,对与肿瘤发生和发展有关的Wnt和Jak Stat等分子进行了表征。2006年,以助理教授的身份加入了纽约医学院的儿科,重点研究了Jak-Stat信号在儿科癌症,特别是急性淋巴细胞白血病中的作用。2012年,移居新加坡,在新加坡国立大学解剖学系担任助理教授。研究利用果蝇遗传学研究了JAK STAT信号转导通路和氧化还原信号转导在干细胞行为和癌症调控中的作用,并研究了纳米材料介导的细胞毒性和遗传毒性的分子机制。将遗传、基因组、分子和细胞生物学技术结合起来,实现对这些复杂过程的系统级理解。曾担任过科学期刊和资助机构的特别评论员,包括生物材料、细胞死亡和分化,以及小型的。他还被任命为众多国际权威期刊和丛书的学术编辑/编辑委员会成员。他有兴趣教人体解剖学,包括组织学的医学、药学和生命科学的学生。

学术著作
  1. Lan Y, Ong R, Muniasamy U, Baeg GH, Ong CN, Yu, LE, Ng CT, Bay BH. Urban PM2.5 reduces angiogenic ability of epithelial cells in an alveolar-capillary co-culture lung model. Submitted.
  2. Ng CT, Ong RXS, Muniasamy U, Baeg GH, Yu L, Ong CN, Bay BH. Carbon black reduced angiogenic ability in endothelial cells in an alveolar-capillary co-culture lung model. Submitted.
  3. Kim BH, Yi EH, Jee JG, Sandoval C, Park IC, Baeg GH*, Ye SK*. The Alangium alkaloid tubulosine is a potent Janus Kinase 3 inhibitor for the treatment of leukemia and lymphoma. Journal of Cellular and Molecular Medicine. (In press).
  4. Ng CT, Yu L, Ong CN, Bay BH, Baeg GH*. (2019). Toxicity Study of Nanoparticles in Cell Culture and Drosophila melanogaster. JoVE. (In press).
  5. Ng CT, Yu L, Ong CN, Bay BH, Baeg GH*. (2018). The use of Drosophila melanogaster as a model organism to study immune-nanotoxicity. Nanotoxicology. Nov 19:1-18.
  6. Yang X, Ng WC, Wong BSE, Baeg GH, Wang CH, Ok YS. (2018). Characterization and ecotoxicological investigation of biochar produced via slow pyrolysis: effect of feedstock composition and pyrolysis conditions. J Hazard Mater. 365:178-185.
  7. Chua PJ, Guo TT, Khanna P, Bay BH, Baeg GH*. (2018). YB-1 plays a role in drug resistance by upregulating JAK/STAT signaling in breast cancer. Int. J. Oncology. 53(6):2579-2589.
  8. Lin WY, Ng WC, Wong BSE, Teo SL, Sivananthan GD, Baeg GH, Ok YS, Wang CH. (2018). Evaluation of sewage sludge incineration ash as a potential land reclamation material. J Hazard Mater. 357:63-72.
  9. Tan WS, Baeg GH*. (2018). Maf-S regulates germline stem cell differentiation in the Drosophila testis. Redox Biology, 15:125-134.
  10. Khanna P, Lee JS, Lee H, Baeg GH* (2018). GRAMD1B inhibits JAK/STAT-mediated cell migration in breast cancer. Scientific Reports, 8(1):9511.
  11. Ng CT, Yu L, Baeg GH, Ong CN, Bay BH. (2018). Biomedical applications of nanomaterials as therapeutics: Biomedical applications of zinc oxide nanomaterials. Current Medicinal Chemistry. 25(12):1409-1419.
  12. Khanna P, Chua PJ, Wong SE, Yin C, Thike AA, Wan WK, Tan PH, Baeg GH*. (2017). GRAM domain-containing protein 1B (GRAMD1B), a novel component of the JAK/STAT signaling pathway functions in gastric carcinogenesis. Oncotarget, 8(70):115370-115383.
  13. Hu Q, Khanna P, Wong SE, Charannya SS, Thanga LZ, Heng SL, Tan WS, Baeg GH*. (2017). Reactive oxygen species induce loss of stemness and spontaneous neuronal differentiation in human embryonic carcinoma NTera2 cells. Oncotarget, 9(3):4223-4238.
  14. Hu Q*, Baeg GH* (2017). Role of Epigenome in Tumorigenesis and Drug Resistance. Food and Chemical Toxicology. S0278-6915(17)30394-0. [Epub ahead of print].
  15. Lim JP, Baeg GH, Kumar SD, Dheen ST, Bay BH (2017). Potential Adverse Effects of Engineered Nanomaterials Commonly Used in Food on the miRNome. Food and Chemical Toxicology. S0278-6915(17)30402-7. [Epub ahead of print].
  16. Wong SE, Hu Q, Baeg GH* (2017). Epigenetic modulations in nanoparticle-mediated toxicity. Food and Chemical Toxicology. S0278-6915(17)30373-3. [Epub ahead of print].
  17. Tan WS, Lee QY, Wong SE, Cai Y, Baeg GH*. (2017). Redox homeostasis plays important roles in the maintenance of the Drosophila testis germline stem cells. Stem Cell Reports. 9:342-354.
  18. Ng CT, Yong LQ, Hande MP, Ong CN, Yu LE, Bay BH, Baeg GH*. (2017). Zinc oxide nanoparticles exhibit cytotoxicity and genotoxicity through oxidative stress responses in human lung fibroblasts and Drosophila melanogaster. International J Nanomedicine. 12:1621-1637.
  19. Zhen X, Rong L, Ong C, Baeg GH, Zhang W, Lee SN, Li SF, Dai Y, Tong YW, Neoh KG, Wang CH. Rapid toxicity screening of gasification ashes. (2016). Waste Management. 50:93-104.
  20. Ong C, Yung LY, Bay BH, Baeg GH*. (2016). Silver nanoparticles induce reproductive toxicity in the male Drosophila melanogaster. Scientific Reports, 6:20632.
  21. Liu Z, Zhong G, Chai PC, Luo L, Liu S, Yang Y, Baeg GH, Cai Y.(2015). Coordinated niche-associated signals promote germline homeostasis in the Drosophila ovary. Journal of Cell Biology. 211(2):469-84.
  22. Khanna P, Chua PJ, Bay BH, Baeg GH*. (2015). The JAK/STAT signaling cascade in gastric carcinoma. International Journal Oncology. 47(5):1617-26.
  23. Ren W, Zhang Y, Li M, Wu L, Wang G, Baeg GH, You J, Li Z, Lin X. (2015). Windpipe controls Drosophila intestinal homeostasis by regulating JAK/STAT pathway via promoting receptor endocytosis and lysosomal degradation. PLoS Genetics. 11(4):e1005180.
  24. Shao F, Guo T, Chua PJ, Tang L, Thike AA, Tan PH, Bay BH, Baeg GH*. (2015). Clinicopathological significance of ARID1B in breast invasive ductal carcinoma. Histopathology. 67(5):709-18.
  25. Khanna P, Ong C, Bay BH, Baeg GH*. (2015). Nanotoxicity: An Interplay of Oxidative Stress, Inflammation and Cell Death. Nanomaterials. 5(3): 1163-1180.
  26. Scully OJ, Yu Y, Salim A, Thike AA, Yip GW, Baeg GH, Tan PH, Matsumoto K, Bay BH. (2015). Complement component 1, q subcomponent binding protein is a marker for proliferation in breast cancer. Experimental Biology and Medicine. 240(7):846-53.
  27. Guo T, Yu Y, Yip GW, Baeg GH, Thike AA, Lim TK, Tan PH, Matsumoto K, Bay BH. (2015). Y-box binding protein 1 is correlated with lymph node metastasis in intestinal-type gastric cancer. Histopathology. 66(4):491-9.
  28. Yin C, Sandoval C, Baeg GH*. (2015). Identification of mutant alleles of JAK3 in pediatric patients with acute lymphoblastic leukemia. Leukemia and Lymphoma. 56(5):1502-6.
  29. Ong C, Yung LY, Cai Y, Bay BH, Baeg GH*. (2015). Drosophila melanogaster as a model organism to study nanotoxicity. Nanotoxicology. 9(3):396-403.
  30. Kim BH, Min YS, Choi JS, Baeg GH, Kim YS, Shin JW, Kim TY, Ye SK. (2011). Benzoxathiol derivative BOT-4-one suppresses L540 lymphoma cell survival and proliferation via inhibition of JAK3/STAT3 signaling. Experimental and Molecular Medicine. 43(5):313-21.
  31. Kim BH, Kim M, Yin CH, Jee JG, Sandoval C, Lee H, Bach EA, Hahm DH, Baeg GH*. (2011). Inhibition of the signalling kinase JAK3 alleviates inflammation in monoarthritic rats. British Journal of Pharmacology. 164(1):106-18.
  32. Yin CH, Bach EA, Baeg GH*. (2011). Development of a high-throughput cell-based reporter assay for screening of JAK3 inhibitors. Journal of Biomolecular Screen. 16(4):443-9.
  33. Kim BH, Jee JG, Yin CH, Sandoval C, Jayabose S, Kitamura D, Bach EA, Baeg GH*. (2010). NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3. Molecular Cancer. 11:9:36.
  34. Kim BH, Oh SR, Yin CH, Lee S, Kim EA, Kim MS, Sandoval C, Jayabose S, Bach EA, Lee HK, Baeg GH*. (2010). MS-1020 is a novel small molecule that selectively inhibits JAK3 activity. British Journal of Haematology. 148(1):132-43.
  35. Kim BH, Yin CH, Guo Q, Bach EA, Lee H, Sandoval C, Jayabose S, Ulaczyk-Lesanko A, Hall DG, Baeg GH*. (2008). A small-molecule compound identified through a cell-based screening inhibits JAK/STAT pathway signaling in human cancer cells. Molecular Cancer Therapeutics. 7(9):2672-80.
  36. Ayala-Camargo A, Ekas LA, Flaherty MS, Baeg GH, Bach EA. (2007). The JAK/STAT pathway regulates proximo-distal patterning in Drosophila. Developmental Dynamics. 236(10):2721-30.
  37. Bach EA, Ekas LA, Ayala-Camargo A, Flaherty MS, Lee H, Perrimon N, Baeg GH*. (2007). GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo. Gene Expression Patterns. 7(3):323-31.
  38. Ekas LA, Baeg GH, Flaherty MS, Ayala-Camargo A, Bach EA. (2006). JAK/STAT signaling promotes regional specification by negatively regulating wingless expression in Drosophila. Development. 133(23):4721-9.
  39. Baeg GH, Zhou R, Perrimon N. (2005). Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. Genes & Development. 19(16):1861-70.
  40. Baeg GH, Selva EM, Goodman RM, Dasgupta R, Perrimon N. (2004). The Wingless morphogen gradient is established by the cooperative action of Frizzled and Heparan Sulfate Proteoglycan receptors. Developmental Biology. 276(1):89-100.
  41. Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, Zhang Z, Lin X, He X. (2002). Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell. 108(6):837-47.
  42. Selva EM, Hong K, Baeg GH, Beverley SM, Turco SJ, Perrimon N, Häcker U. (2002). Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events. Nature Cell Biology. 3(9):809-15.
  43. Baeg GH, Lin X, Khare N, Baumgartner S, Perrimon N. (2001). Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless. Development. 128(1):87-94.
  44. Baeg GH, Perrimon N. (2000). Functional binding of secreted molecules to heparan sulfate proteoglycans in Drosophila. Current Opinion in Cell Biology. 12(5):575-80.
  45. Adachi J, Kohno T, Baeg G, Akiyama T, Yokota J. (1997). Growth suppression of non-small cell lung carcinoma cells by the introduction of the p16 (INK4A) gene. International Journal of Oncology. 10(1):33-9.
  46. Higuchi O, Baeg GH, Akiyama T, Mizuno K. (1996). Suppression of fibroblast cell growth by overexpression of LIM-kinase 1. FEBS Letter. 396(1):81-6.
  47. Senda T, Miyashiro I, Matsumine A, Baeg GH, Monden T, Kobayashil S, Monden M, Toyoshima K, Akiyama T. (1996). The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells. Biochemical and Biophysical Research Communications. 223(2):329-34.
  48. Matsumine A, Ogai A, Senda T, Okumura N, Satoh K, Baeg GH, Kawahara T, Kobayashi S, Okada M, Toyoshima K, Akiyama T. (1996). Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. Science. 272(5264):1020-3.
  49. Matsumine A, Senda T, Baeg GH, Roy BC, Nakamura Y, Noda M, Toyoshima K, Akiyama T. (1996). MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase. Journal of Biological Chemistry. 271(17):10341-6.
  50. Baeg GH, Matsumine A, Kuroda T, Bhattacharjee RN, Miyashiro I, Toyoshima K, Akiyama T. (1995). The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase. EMBO J. 14(22):5618-25.
  51. Miyashiro I, Senda T, Matsumine A, Baeg GH, Kuroda T, Shimano T, Miura S, Noda T, Kobayashi S, Monden M, et al. (1995). Subcellular localization of the APC protein: immunoelectron microscopic study of the association of the APC protein with catenin. Oncogene. 11(1):89-96.
  52. Baeg GH, Sakurai Y. and Shimazaki K. (1993). Maturation processes in female Loligo Bleekeri Keferstein (Mollusca: Cephalopoda). The Veliger. 36; 228-235.
  53. Baeg GH, Sakurai Y. and Shimazaki K. (1992). Embryonic stages of Loligo Bleekeri Keferstein (Mollusca: Cephalopoda). The Veliger. 35; 234-241.