博士 (中国科学技术大学)

学士 (中南大学湘雅医学院)

杜洋教授于中南大学湘雅医学院和中国科学技术大学分别取得学士和博士学位，之后赴美国斯坦福大学医学院分子与细胞生理学系，师从2012年诺贝尔化学奖得主布莱恩·科比尔卡(Brian Kobilka)教授，从事G蛋白偶联受体(GPCR)相关的博士后研究训练，并于2016年底转为斯坦福医学中心研究科学家。期间获授美国心脏协会(American Heart Association)全额博士后奖学金和斯坦福心血管研究所资助等，并获得美国密歇根大学安娜堡分校医学院助理教授职位。主要研究方向是以β2肾上腺素受体等重要药物靶点的GPCR为对象，研究其与下游信号分子复合物的结构、功能和分子药理特性。

杜教授迄今已发表60余篇高质量SCI论文，包括以通讯或第一作者(含共同)在Cell、Science、Nature Comm、Science Advances、Cell Research、JACS等国际一流期刊等报道的科研成果，并受邀为Science、Nature Comm等多种国际主流科学杂志审稿。现为香港中文大学（深圳）医学院助理教授、博士生导师，科比尔卡创新药物开发研究院研究员。杜教授于2021年起作为教育部特聘专家，已入选国家级、广东省和深圳市等各级高层次人才项目，获得深圳市优秀教师、校长模范教学奖和大学青年科研创新奖等荣誉奖励，并主持国自然和深圳市重点等多个科研项目。
 

主要论文：

20 Wong TS*, Li G*, Li S*, Gao W, Chen G, Gan S, Zhang M, Li H#, Wu S#, Du Y#. G protein-coupled Receptors in Nervous System and Neuropsychiatric Disorders. Signal Transduction and Targed Therapy, 2023 May 3;8(1):177. doi: 10.1038/s41392-023-01427-2.
19 Xu J, Cao S, Hubner H, Weikert D, Chen G, Lu Q, Yuan D, Gmerner P#, Liu Z#, Du Y#. Structural insights into ligand recognition, activation and signaling bias of the α2A adrenergic receptor. Science Advances, 2022, Mar 4;8(9):eabj5347
18 Chen G, Xu J, Inoue A, Schmidt MF, Bai C, Lu Q, Gmerner P#, Liu Z#, Du Y#. Structure of the orphan GPR88-Gi complex reveals unique ligand binding and signaling mechanism. Nature Commun., 2022, May 2;13(1):2375.
17 Du Y*, Duc NM*, Rasmussen SGF*, Hilger D, Kubiak X, Wang L, Kim HR, Wegrecki M, Asuru A, Jeong KM, Lee J, Chance M, Lodowski DT, Kobilka BK, Chung KY. Assembly of a GPCR-G protein complex. Cell, 2019, 177(5):1232-1242
16 Wang Q*, Lu Q*, Guo Q, Teng M, Gong Q, Li X, Du Y#, Liu Zheng#, Tao Y#. Structural basis of the ligand binding and signaling mechanism of melatonin receptors. Nature Commun., 2022 Jan 24;13(1):454.
15 Flink EA*, Xu J*, Hubner H*, Braz J*, Seemann P*, Avet C, Craik V, Weikert D, Schmidt MF, Webb CM,    Tolmachova NA, Moroz Y, Kalyanaraman C, Gahbauer S, Chen G, Jacobson MP, Irwin J, Du Y#, Schoichet BK, Huang XP, Kalyanaraman C, Gahbauer S, Chen G, Liu Z, Jacobson MP, Irwin JJ, Mouvier M, Du Y, Schoichet BK, Basbaum AI, Gmerner P. Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor. Science, 2022 Sep 30;377(6614):eabn7065
14 Chen G, Wang X, Liao Q, Ge Y, Jiao H, Chen Q, Liu Y, Du Y#, Hu H#, Ye RD#. Structural Basis for Recognition of N-Formyl Peptides as Pathogen- and Damage- associated Molecular Patterns. Nature Commun., 2022 Sep 5;13(1):5232
13 Wong TS*, Li G*, Li S*, Gao W, Chen G, Gan S, Li C, Liang M, Zhang S, Feng Z, Zhang M, Ye RD, Li H#, Wu S#, Du Y#. G protein-coupled Receptors in Nervous System and Neuropsychiatric Disorders. Signal Transduction and Targed Therapy, 2022, under revision
12 Chen G*, Gao W, Du Y#. Identification of a Sialosides binding pocket in early- lineage Sars-Cov-2 virus via an optimized STD NMR method: a novel explanation for coronavirus virulence and zoonosis. Molecular Biomedicine, 2022, accepted
11 Xiao P*, Yan W*, Gou L*, Zhong YN*, Kong L*, Wu C, Wen X, Yuan Y, Qu C, Yang X, Zhang C, Xia A, Yang CC, Hou GH, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y#, Zhang L#, Yu X#, Shao Z#. Ligand recognition and allosteric regulation of dopamine D1 receptor-Gs signaling complexes. Cell, 2021, 184(4):943-956
10 Wang L*, Xu J*, Cao S, Sun D, Liu H, Liu Z, Du Y#, Zhang C#. Cryo-EM structure of the AVP-vasopressin receptor 2-Gs signaling complex. Cell Research, 2021, doi: 10.1038/s41422-021-00483-z
9 Kim HR*, Xu J*, Maeda S, Duc NM, Ahn D, Du Y#, Chung KY. Structural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family. Nat Commun. 2020 Jun 22;11(1):3160
8 Bai C#, Wang J, Chen G, Zhang H, Xu P, Du Y#, Ye RD#, Saha A, Zhang A, Warshel A#. Predicting Mutational Effects on Receptor Binding of the SARS-CoV-2 Variants. J Am Chem Soc., 2021, 143, 42, 17646–17654
7 Komolov KE*, Du Y*, Duc NM, Betz R, Rodrigues J, Leib RD, Patra D, Skiniotis G, Adams CM, Dror R, Chung KY, Kobilka BK, Benovic JL. Structural and functional analysis of a β2-Adrenergic Receptor Complex with GRK5. Cell (2017) 169: 407-421
6 Das M*, Du Y*, Ribeiro O, Hariharan P, Mortensen JS, Patra D, Skiniotis G, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae, PS. Conformationally preorganized diastereomeric norbornane-based maltosides (NBMs) for membrane protein study: Implications of detergent kink for micellar properties. J. Am. Chem. Soc. (2017) 139: 3072-81
5 Ehsan M*, Du Y*, Scull NJ, Tikhonova E, Tarrasch J, Mortensen JS, Loland CJ, Skiniotis G, Guan L, Byrne B, Kobilka BK, Chae PS. Highly Branched Penta- Saccharide-Bearing Amphiphiles for Membrane Protein Studies. J. Am. Chem. Soc. (2016) 138: 3789-96
4 Sadaf A*, Du Y*, Hariharan P, Mortensen JS, Perez IM, Seven AB, Santillan C, Skiniotis G, Loland CJ, Kobilka BK, Guan L, Byrne B, Chae PS. Dendronic trimaltoside amphiphiles (DTMs) for membrane protein structure study. Chemical Science (2017) 8: 1169-1177
3 Duc NM*, Du Y*, Thorsen TS, Lee SY, Zhang C, Kato H, Kobilka BK, Chung KY. Effective Application of Bicelles for Conformational Analysis of G Protein-Coupled Receptors by Hydrogen/Deuterium Exchange Mass Spectrometry. J. Am. Soc.
Mass. Spectrom. (2015) 26: 808-817
2 Du Y*, Shi WW*, He YX, Yang YH, Zhou CZ, Chen Y. Structures of the substrate- binding protein provide insights into the multiple compatible solutes binding specificities of Bacillus subtilis ABC transporter OpuC. Biochemical J. (2011) 436: 283-289
1 Du Y*, He YX*, Zhang ZY, Yang YH, Shi WW, Frolet C, Di Guilmi AM, Vernet T, Zhou CZ, and Chen Y. Crystal structure of the mucin-binding protein of Spr1345 from Streptococcus pneumoniae. J. of Struct. Biol. 2011, 174: 252-257