REN, Ruobing

Assistant Professor

Education Background

PhD (Tsinghua University)

BS (University of Science  and Technology of China)

Research Field
Cholesterol metabolism;Lipidology; GPCR; Transporting machinery (Ion channels and transporters)

Dr. Ren, Ruobing received his bachelor's degree in biotechnology from the School of Life Sciences of University of Science and Technology of China in 2009. Then he joined in Professor Shi, Yigong’s group (world's leading structural biologist, member of CAS, foreign member of AAAS, NAS and EMBO) in Tsinghua University focusing on the molecular mechanism of cholesterol metabolism regulation and received PhD in Structural Biology and Biochemistry in 2015. During 2015-2017, he worked as an associate scientist at Amgen (one of the leading multinational biotechnology company) Asia R&D Center and participated in the development of two therapeutic molecules targeting G-protein coupled receptor. Since Dec. 2017, he joined in the Chinese University of Hong Kong, Shenzhen School of Science and Engineeringas and Kobilka Institute of Innovative Drug Discovery as assistant professor, then joined School of Life and Health Sciences at beginning of  2019.

Dr. Ren has focused on the structures and molecular mechanisms of membrane proteins with biological significance using a combination of state-of-the-art structural (X-ray crystallography, cryo-EM) and biochemical/biophysical techniques for over 10 years. As first author, he has published several research articles in the world's leading journals such as Science, Journal of Biological Chemistry and so on. The Science paper firstly provided structural and mechanistic insights for cholesterol sensing on ER. The JBC paper elucidated the molecular mechanism of dephosphorylation of SnRK2.6, which is the key step for abscisic acid (one of the most important plant hormones) signaling transduction. He is the National Leading Talent of Shenzhen from 2018.

Academic Publication

1. Ren R*, et al. 2015. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels. Science. 349(6244):187-91.

2. Gong X, Li J, Shao W, Wu J, Qian H, Ren R, et al. 2015. Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition. Cell Res. 25(4):401-11.

3. Xie T*, Ren R*, et al. 2012. Molecular mechanism for inhibition of a critical component in the Arabidopsis thaliana abscisic acid signal transduction pathways, SnRK2.6, by protein phosphatase ABI1. J Biol Chem. 287(1):794-802.