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— Faculty —

YE, Richard


Presidential Chair Professor, Dean

Education Background

Ph.D. (Washington University)

Research Field
Pharmacology, Immunology


Professor Ye Dequan graduated from Shanghai Second Medical College in 1982 and received his Ph.D. from Washington University in St. Louis, USA in 1988. Since 1989, he has served as an Assistant Professor, Associate Professor, and Professor at the Scripps Research Institute and the University of Illinois Medical School. His research projects have been continuously funded by the National Institutes of Health for 25 years. His main research interests include signal transduction of G protein-coupled receptors and their role in innate immune cells, inflammatory mechanisms and pathological models and the discovery of related drug targets. He has cooperated with Johnson & Johnson, Novartis, GSK and other companies to develop R&D cooperation. As the first inventor, he was granted 2 US patents, 1 Chinese patent, and 2 joint inventor patents. Published 198 academic papers on SCI and was cited more than 10,000 times. In 2010, he returned to China as Chair Professor at Shanghai Jiao Tong University and Dean of the School of Pharmacy; from January 2015 to January 2019, he served as Chair Professor at the University of Macau. Academic part-time work includes Associate Editor of FASEB Journal, Associate Editor of Pharmacological Reviews, Associate Editor of Physiology Reviews, Molecular Pharmacology and the editorial board of the British Journal of Pharmacology.

Academic Publications:

1,  Cheng N, Liang Y, Du X, Ye, RD. Serum amyloid A promotes LPS clearance andsuppresses LPS-induced inflammation and tissue injury. EMBO Reports 2018 Oct;19(10). pii: e45517;  doi: 10.15252/embr.201745517. PMID: 30126923

2,  Zhang G, Liu J, Wu L, Fan Y, Sun L, Qian F, Chen D, Ye RD. Elevated expression of serum amyloid A 3 protects colon epithelium against acute injury through TLR2-dependent induction of neutrophil IL-22 expression in a mouse model of colitis. Front. Immunol. 2018 Jun 29; 9:1503. doi: 10.3389/fimmu.2018.01503. PMID: 30008720 

3,  Zheng C, Chen D, Zhang Y, Bai Y, Huang S, Zheng D, Liang W, She S, Peng X, Wang P, Mo X, Song Q, Lv P, Huang J, Ye RD, Wang Y. FAM19A1 is a new ligand for GPR1 that modulates neural stem-cell proliferation and differentiation. FASEB J. 2018 May 25:fj201800020RRR. PMID: 29799787

4,  Zhou H, Chen M, Zhang G, Ye RD. Suppression of Lipopolysaccharide-Induced Inflammatory Response by Fragments from Serum Amyloid A. J Immunol. 2017 Aug 1;199(3):1105-1112,doi: 10.4049/jimmunol.1700470.

5,  Zhu Z, Wang L, Hao R, Zhao B, Sun L, Ye RD. Cutting Edge: A Cullin-5-TRAF6 interaction promotes TRAF6 polyubiquitination and lipopolysaccharide signaling. J Immunol. 2016 Jul 1;197(1):21-6. PMID: 27233966.

6,  Ye, R.D., Sun, L. (2015) Emerging functions of serum amyloid A in inflammation. J Leukoc. Biol. 98:923-929. PMID: 26130702.

7,  Ye, R.D. (2014) STIM1 for stimulation of phagocyte NADPH oxidase. Blood 123:2129-30. doi: 10.1182. PMCID: PMC3975253.

8,  Naikawadi, R.P., Cheng, N., Vogel, S. M., Qian, F., Wu, D., Malik, A. B., & Ye, R. D. (2012). A Critical Role for Phosphatidylinositol (3, 4, 5)-Trisphosphate–Dependent Rac Exchanger 1 in Endothelial Junction Disruption and Vascular Hyperpermeability.  Circ. Res. 111, 1517-1527.

9,  Liu, X., Ma, B., Malik, A.B., Tang, H., Yang, T., Sun, B., Wang, G., Minshall, R.D., Li, Y., Zhao, Y., Ye, R.D. and Xu, J. (2012) Bidirectional Regulation of Neutrophil Migration by MAP Kinases. Nat. Immunol. 13:257-264. (R.D. Ye and J. Xu, co-corresponding authors).

10,Ye, R.D., Boulay, F., Wang, J.M., Dahlgren, C., Gerard, C., Parmentier, M., Serhan, C.N., and Murphy, P.M. (2009) International Union of Pharmacology: Nomenclature for the formyl peptide receptor (FPR) family.  Pharmacol. Rev. 61:119-161.