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KOBILKA, Brian

Title:

Distinguished Professor At Large, Nobel Laureate in Chemistry (2012), Member of the USA National Academy of Sciences

Education Background

M.D. (Yale University School of Medicine)

B.S. (University of Minnesota)

Research Field
G Protein Coupled Receptors
Email

kobilka@stanford.edu

Biography:


Prof. Brian Kobilka is currently a professor in the department of Molecular and Cellular Physiology at Stanford University School of Medicine. He is also the co-founder of ConfometRx, a biotechnology company focusing on G protein-coupled receptors. He was named a member of the National Academy of Sciences in 2011. He is a recipient of the 2012 Nobel Prize in Chemistry with Robert Lefkowitz for discoveries that reveal the inner workings of an important family G protein-coupled receptors. 


Academic Publications:


Selected Publications

1. Sounier, R. Mas, C, Steyaert, J., Laeremans, T. Manglik, A., Huang, W., Kobilka, B.K., Demene, H., Granier, S. Propagation of conformational changes during μ-opioid receptor activation. Nature August 2015.

2. Huang, W., Manglik, A., Venkatakrishnan, A.J., Laeremans, T., Feinberg, E.N., Sanborn, A.L., Kato, H.E., Livingston, K.E., Thorsen, T.S., Kling, R.C., Granier, S., Gmeiner, P., Husbands, S.M., Tryanor, J.R., Weis, W.I., Steyaert, J., Dror, R.O., Kobilika, B.K. Structural Insights into μ-opioid receptor activation. Nature August 2015.

3. Dror, R. O., Mildorf, T. J., Hilger, D., Manglik, A., Borhani, D. W., Arlow, D. H., Philippsen, A., Villanueva, N., Yang, Z., Lerch, M. T., Hubbell, W. L., Kobilka, B. K., Sunahara R. K., and Shaw, D. E.  Structural basis for nucleotide exchange in heterotrimeric G proteins. Science 348(6241), 1361-1365 (2015).

4. Manglik, A., Kim, T. H., Masureel, M., Altenbach, C., Yang, Z., Hilger, D., Lerch, M. T., Kobilka, T. S.,Thian, F. S., Hubbell, W. L., Prosser, R. S., and Kobilka, B. K. Structural insights into the dynamic process of β2-adrenergic receptor signaling. Cell 161(5), 1101-1111 (2015).

5. Alsteens, D., M. Pfreundschuh, C. Zhang, P. M. Spoerri, S. R. Coughlin, B. K. Kobilka and D. J. Muller. Imaging G protein-coupled receptors while quantifying their ligand-binding free-energy landscape. Nat Methods July (2015).

6. Thorsen, T. S., Matt, R., Weis, W. I. and Kobilka, B. K. Modified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis. Structure 22, 1657-1664 (2014).

7. Shukla, A.K., Westfield, G.H., Xiao, K., Reis, R.I., Huang, L.-Y., Tripathi-Shukla, P., Qian, J., Li, S., Blanc, A., Oleskie, A.N., Dosey, A.M., Su, M., Liang, C.-R., Gu, L.-L., Shan, J.-M., Chen, X., Hanna, R., Choi, M., Yao, X.J., Klink, B.U., Kahsai, A.W., Sidhu, S.S., Koide, S., Penczek, P.A., Kossiakoff, A.A., Woods Jr, V.L., Kobilka, B.K., Skiniotis, G. and Lefkowitz, R.J. Visualization of arrestin recruitment by a G-protein-coupled receptor. Nature 512, 218-22 (2014).

8. Staus, D. P., Wingler, L. M., Strachan, R. T., Rasmussen, S. G., Pardon, E., Ahn, S., Steyaert, J., Kobilka, B. K.  and Lefkowitz, R. J. Regulation of beta2-adrenergic receptor function by conformationally selective single-domain intrabodies. Mol Pharmacol 85(3), 472-481 (2014).

9. Kruse, A.C., Ring, A.M., Manglik, A., Hu, J., Hu, K., Eitel, K., Hübner, K., Pardon, E., Valant, C., Sexton, P.M., Christopoulos, A., Felder, C.C., Gmeiner, P., Steyaert, J., Weis, W.I., Garcia, K.C., Wess, J., Kobilka, B.K. Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature 504, 101-6 (2013).

10. Ring, A.M., Manglik, A., Kruse, A.C., Enos, M.D., Weis, W.I., Garcia, K.C., Kobilka, B.K. Adrenaline-activated structure of the beta 2-adrenoceptor stabilized by an engineered nanobody. Nature 502, 575-579 (2013).

11. Shukla, A. K., Manglik, A., Kruse, A.C., Xiao, Reis, K. R. I., Tseng, W. C., Staus, D. P., Hilger, D., Uysal, S., Huang, L. Y., Paduch, M., Tripathi-Shukla, P., Koide, A., Koide, S., Weis, W. I., Kossiakoff, A. A., Kobilka, B. K.  and Lefkowitz, R. J. Structure of active beta-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature 497, 137-141 (2013).

12. Nygaard, R., Zou, Y., Dror, R. O., Mildorf, T. J., Arlow, D. H., Manglik, A., Pan, A. C., Liu, C. W., Fung, J. J., Bokoch, M. P., Thian, F. S., Kobilka, T. S., Shaw, D. E., Mueller, L., Prosser, R. S. & Kobilka, B. K. The Dynamic Process of beta(2)-Adrenergic Receptor Activation. Cell 152, 532-542 (2013).

13. Zhang, C., Srinivasan, Y., Arlow, D. H., Fung, J. J., Palmer, D., Zheng, Y., Green, H. F., Pandey, A., Dror, R. O., Shaw, D. E., Weis, W. I., Coughlin, S. R. & Kobilka, B. K.High-resolution crystal structure of human protease-activated receptor 1. Nature 492, 387-392 (2012).

14. Zou, Y., Weis, W. I. & Kobilka, B. K. N-terminal T4 lysozyme fusion facilitates crystallization of a G protein coupled receptor. PLoS One 7, e46039 (2012).

15. Chung, K.Y., Kim, T.H., Manglik, A., Alvares, R., Kobilka, B.K., and Prosser, R.S. The role of detergents on conformational exchange of a G protein-coupled receptor. J Biol Chem 287, 36305-36311 (2012).